HOPA DEFINED. A new field has been created in the MLS so that members can identify those developments that are certified to be over 55 communities. Definition of Homeowners Protection Act (HOPA): Legislation passed in in response to abuses by some private mortgage insurance (PMI) issuers. In cases. Find out what is the full meaning of HOPA on listsmileys.review! 'Hematology/ Oncology Pharmacy Association' is one option -- get in to view more @ The Web's.